Dr. Jonathan C. Trent earned his MD and PhD in cancer biology from The University of Texas Health Science Center where he also completed a residency in internal medicine. He then completed a fellowship in medical oncology at The University of Texas M. D. Anderson Cancer Center while serving as chief fellow. Prior to joining the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, he held an appointment as associate professor of medicine in the Department of Sarcoma Medical Oncology, Division of Cancer Medicine at the University of Texas M. D. Anderson Cancer Center in Houston. Dr. Trent is currently the Associate Director for Clinical Research at the Sylvester Comprehensive Cancer Center and the Director of the Bone and Soft-tissue Sarcoma Group.
Dr. Trent’s interests are in the clinical and translational research of sarcomas, direct care of sarcoma patients, and education about sarcoma. As Associate Director for Clinical Research, his goal is to develop clinical trials that provide molecular testing of a patient’s tumor and molecularly targeted therapy to cancer patients of South Florida and beyond.
The major focus of his clinical, educational and research efforts are with gastrointestinal stromal tumors (GIST) and all other sarcomas including myxofibrosarcoma, leiomyosarcoma, liposarcoma, chondrosarcoma, angiosarcoma, synovial sarcoma, pigmented villonodular synovitis, dermatofibrosarcoma protuberans perivascular endothelial cell sarcoma (PEComa), angiomyolipoma, alveolar soft-parts sarcoma, and rhabdomyosarcoma. The major efforts of Dr. Trent’s research focus on understanding the mechanisms of action and resistance of imatinib in GIST and other sarcomas while striving toward improved therapeutic options. His work involves the use of novel preoperative/postoperative clinical trials, prospectively acquired tumor tissue, cell lines, archival tissue, as well as collaborations with disciplines such as the genomics facility, surgical oncology, pathology, radiology and interventional radiology.